Wow ya gotta love ClickZ for all its wisdom. This is a very worthwhile read and in my opinion this is one mistake I see and hear about all the time:

Using a Small E-Mail Application to Send Volume E-Mail
Sending commercial e-mail through Outlook or GoldMine may cost less than using an e-mail program designed to create and send volume mailings, but these clients and the small-time server you use to send personal e-mail aren’t designed to handle high-volume deliveries. You also don’t get the e-mail reports, tracking, volume control, segmentation, and other benefits that are becoming standard on even basic e-mail delivery platforms.

For the other 9 no-no’s, go here…

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